Evidence supporting the use of Combretum nigricans as an antimalarial agent in ethnomedicine

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dc.creatorEnegide, Chinedu
dc.creatorAkah, Peter
dc.creatorOfili, Charles
dc.creatorAgatemor, Uzuazokaro
dc.creatorAmeh, Solomon
dc.creatorDabum, Jacob
dc.creatorOnah, Ifeoma
dc.date.accessioned2026-01-10T19:04:01Z
dc.date.available2026-01-10T19:04:01Z
dc.date.issued2021-05-24
dc.descriptionBackground: Combretum nigricans (Combretaceae) is a small, smooth bark tree used in traditional medicine for the treatment of prurigo, dysentery, fever and other symptoms of acute malaria in North-Central Nigeria. Materials and Methods: The antimalarial activity of C nigricans hydro-methanol crude leaf extract was evaluated against Plasmodium berghei in mice. The Peters’ 4-day suppressive test against early malaria infection and Rane’s curative test against established malaria were employed in assessing the antimalarial activity of the crude extract. In each test model, five groups containing five mice each were used. Group 1 mice were administered with 10 ml distilled water/kg b.w. p.o., groups 2 - 4 were administered with 200, 400, and 800 mg extract/kg b.w. p.o. respectively, while group 5 mice were administered with artesunate 10 mg/kg b.w. p.o. Result: All doses of C. nigricans extract employed for the study (200 – 800 mg/kg b.w. p.o.) gave significant (P<0.05) chemosuppressive effect against P. berghei, this effect was observed to be dose-related; while the 400 mg/kg extract dose gave the highest curative effect. Compared to control, the extract also prolonged the mean survival time at all doses, and as well prevented the characteristic decrease in body temperature elicited by P. berghei in mice. The LD50 of the extract was >5000 mg/kg b.w. p.o. in mice. Conclusion: The result from the study indicates that C. nigicans crude leaf extract is safe orally and possesses significant antimalarial activity.en-US
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dc.identifierhttps://sumathipublications.com/index.php/ijcrpp/article/view/408
dc.identifier10.31878/ijcrpp.2021.52.02
dc.identifier.urihttps://repos.sumathipublications.com:8000/handle/123456789/240
dc.languageeng
dc.publisherSumathi Publicationsen-US
dc.relationhttps://sumathipublications.com/index.php/ijcrpp/article/view/408/404
dc.relation.ispartofInternational Journal of Current Research in Physiology and Pharmacologyen-US
dc.relation.ispartofseriesVolume 5, Issue 2en-US
dc.rightsCopyright (c) 2021 Chinedu Enegide, Peter Akah, Charles Ofili, Uzuazokaro Agatemor, Solomon Ameh, Jacob Dabum, Ifeoma Onahen-US
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceInternational Journal of Current Research in Physiology and Pharmacology; Volume 5, Issue 2; 2021; 13-20en-US
dc.source2523-6709
dc.source2523-6695
dc.subjectCombretum nigricansen-US
dc.subjectAntimalarialen-US
dc.subjectIn vivoen-US
dc.subjectPlasmodium bergheien-US
dc.titleEvidence supporting the use of Combretum nigricans as an antimalarial agent in ethnomedicineen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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