PREPARATION AND EVALUATION OF TRANSNASAL MICROEMULSION OF VIGABATRIN

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dc.creatorN Tarkase, Kailash
dc.creatorV Nimbalkar, Vikram
dc.creatorR Kale, Madhurima
dc.date.accessioned2026-01-10T18:52:59Z
dc.date.available2026-01-10T18:52:59Z
dc.date.issued2017-10-25
dc.descriptionIntroduction: The objective of this study was to develop novel transnasal microemulsion containing Vigabatrin for treatment of epilepsy. Method: Oleic acid was selected as oil while Tween 80 and ethanol were selected as surfactant and co-surfactant respectively based on solubility results. Optimized ratio of Tween 80 and Ethanol was selected after developing pseudoternary phase diagrams for different ratio and microemulsions were prepared. The prepared microemulsions were evaluated for globule size, viscosity, pH, and % transmittance. Ex-vivo diffusion study for optimized microemulsion was performed through goat nasal mucosa where in diffusion flux and permeability coefficients were determined. Pharmacological performance was screened in rats by electrically induced seizures. Result: It was found that op mized microemulsion was stable and transparent. Pharmacological evaluation indicated significant reduction (p<0.001) of seizures in rats treated with optimized formula on in comparison to rats treated with oral Vigabatrin microemulsion and nasal Vigabatrin solu on which suggested Vigabatrin transnasal delivery system as an effective alternate therapy for treatment of epilepsy. Conclusion: Transnasal microemulsion of Vigabatrin was successfully formulated using Tween 80 as surfactant and ethanol as co-surfactant in the formula on to treat epilepsy. Key words: Epilepsy; Transnasal Microemulsion; Vigabatrin.en-US
dc.formatapplication/pdf
dc.identifierhttps://sumathipublications.com/index.php/ijcbr/article/view/172
dc.identifier10.5455/ijcbr.2017.34.12
dc.identifier.urihttps://repos.sumathipublications.com:8000/handle/123456789/169
dc.languageeng
dc.publisherSumathi Publicationsen-US
dc.relationhttps://sumathipublications.com/index.php/ijcbr/article/view/172/198
dc.relation.ispartofInternational Journal of Clinical and Biomedical Researchen-US
dc.relation.ispartofseriesVolume 3, Issue 4en-US
dc.rightsCopyright (c) 2017 Kailash N Tarkase, Vikram V Nimbalkar, Madhurima R Kaleen-US
dc.sourceInternational Journal of Clinical and Biomedical Research; Volume 3, Issue 4; October 2017; 54-59en-US
dc.source2395-0471
dc.source2521-0394
dc.titlePREPARATION AND EVALUATION OF TRANSNASAL MICROEMULSION OF VIGABATRINen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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