LIPID PROFILE AND LIPID PEROXIDATION IN BRONCHIAL ASTHMA

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dc.creatorParhi, Kamala Kanta
dc.creatorPK, Behera
dc.creatorChatterjee, Gangadhar
dc.date.accessioned2026-01-10T18:53:04Z
dc.date.available2026-01-10T18:53:04Z
dc.date.issued2018-04-15
dc.descriptionBackground: Bronchial asthma, a chronic inflammatory condition, often triggered by allergy & oxidative stress, initiate lipid peroxidation& enhanced release of arachidonic acid from cell membrane. Regarding lipid profile in bronchial asthma patients many conflicting data were reported. Therefore we have conducted this study. Methodology: 50 clinically diagnosed bronchial asthma cases for lipid profile and lipid peroxidation levels were compared with 50 healthy controls. Results: In our study fasting serum HDL and LDL cholesterol level of cases respectively (52.32mg/dl ±3.58), (99.21mg/dl ±12.49) were found to be significantly higher when compared to controls (44.58mg/dl ±2.58), (103.44mg/dl ±10.55) (p-value <0.05). Mean plasma SOD level of cases (3.42 U/mL±0.74) was significantly lowered than controls (7.16 U/mL±0.52). Serum MDA level of cases (5.91nmol/L±0.88) was higher as compared to controls (3.00nmol/L±0.40). (p-value <0.001) Conclusion: Lipid profile in bronchial asthma patients (raised HDL& decreased LDL) provides some degree of protection to this patients against ischemic heart disease (IHD). But increased in lipid peroxidation as evidenced by decrease plasma SOD & raised serum MDA aggravate airway inflammation, smooth muscle contraction & increased vascular permeability Keywords: Asthma; Oxidative stress; Lipid peroxidation; Lipid profile.en-US
dc.formatapplication/pdf
dc.identifierhttps://sumathipublications.com/index.php/ijcbr/article/view/201
dc.identifier10.5455/ijcbr.2018.42.11
dc.identifier.urihttps://repos.sumathipublications.com:8000/handle/123456789/188
dc.languageeng
dc.publisherSumathi Publicationsen-US
dc.relationhttps://sumathipublications.com/index.php/ijcbr/article/view/201/234
dc.relation.ispartofInternational Journal of Clinical and Biomedical Researchen-US
dc.relation.ispartofseriesVolume 4, Issue 2en-US
dc.rightsCopyright (c) 2018 Kamala Kanta Parhi, Behera PK, Gangadhar Chatterjeeen-US
dc.sourceInternational Journal of Clinical and Biomedical Research; Volume 4, Issue 2; April 2018; 47-51en-US
dc.source2395-0471
dc.source2521-0394
dc.titleLIPID PROFILE AND LIPID PEROXIDATION IN BRONCHIAL ASTHMAen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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