Exploring the Therapeutic Potential of Moringa Oleifera in Lead Poisoning: An Investigation of its Effects on Blood Lead Levels and Oxidative Stress in Rats

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dc.creatorEjike, Onah Christian
dc.creatorFlorence, Onah Chinwemma
dc.creatorFriday, Ehiaghe Alfred
dc.creatorAthanasius, Onyegbule Onyema
dc.creatorChukwuemeka, Ogbodo Emmanuel
dc.creatorUkamaka, Ijeomah Ann
dc.creatorSerah, Nnaemeka Wuraola
dc.creatorChukwuemeka, Meludu Samuel
dc.creatorEmmanuel, Dioka Chudi
dc.date.accessioned2026-01-10T19:35:57Z
dc.date.available2026-01-10T19:35:57Z
dc.date.issued2023-03-26
dc.descriptionObjective: Lead poisoning is a global public health problem that has been associated with poor treatment outcomes. We therefore evaluated the ability of Moringa oleifera (M. oleifera) to reduce blood lead level (BLL) and lead-induced oxidative stress in relation to dimercaptosuccinic acid (DMSA) in albino wister rats. Methods: Thirty rats were allocated into five groups consisted of 6 rats each. Control group (A) received normal rat chow and water ad libitum for 12 weeks. Group (B-E) initially received 100 mg/kg body weight lead acetate per oral for 6 weeks. Thereafter, groups B, C, D and E received DMSA and different doses of M. oleifera and their combination for another 6 weeks. Blood samples were collected prior to treatment, 6 weeks, and 12 weeks post-treatment for the analysis of BLL, malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione-s-transferase (GST). Results: BLL and MDA increased significantly (p<0.05) while serum SOD, CAT, and GST activities decreased significantly (p<0.05) from their pre-treatment levels after 6 weeks of lead acetate administration. However, 400 mg/kg body weight M. oleifera administration after 12 weeks post-treatment significantly (p<0.05) decreased 6 weeks BLL by (40.5%); MDA (52%); and significantly (p<0.05) increased the activities of serum SOD by (35%); CAT (26.3%); and GST (53%). Conclusion: M. oleifera was observed to not only effectively reduce blood lead levels but also ameliorate lead induced oxidative stress through enhanced antioxidant activities. M. oleifera may therefore, serve as an alternative therapeutic approach to lead poisoning especially in resource limited settings.en-US
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dc.identifierhttps://sumathipublications.com/index.php/ijcbr/article/view/449
dc.identifier.urihttps://repos.sumathipublications.com:8000/handle/123456789/378
dc.languageeng
dc.publisherSumathi Publicationsen-US
dc.relationhttps://sumathipublications.com/index.php/ijcbr/article/view/449/526
dc.relationhttps://sumathipublications.com/index.php/ijcbr/article/view/449/530
dc.relationhttps://sumathipublications.com/index.php/ijcbr/article/view/449/531
dc.relationhttps://sumathipublications.com/index.php/ijcbr/article/view/449/532
dc.relation.ispartofInternational Journal of Clinical and Biomedical Researchen-US
dc.relation.ispartofseriesVolume 9, Issue 2en-US
dc.rightsCopyright (c) 2023 Onah Christian Ejike, Onah Chinwemma Florence, Ehiaghe Alfred Friday, Onyegbule Onyema Athanasius, Ogbodo Emmanuel Chukwuemeka, Ijeomah Ann Ukamaka, Nnaemeka Wuraola Serah, Meludu Samuel Chukwuemeka, Dioka Chudi Emmanuelen-US
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceInternational Journal of Clinical and Biomedical Research; Volume 9, Issue 2; 2023; 1-6en-US
dc.source2395-0471
dc.source2521-0394
dc.subjectAntioxidants; Lead toxicity; Moringa oleifera; dimercaptosuccinic acid; oxidative stressen-US
dc.titleExploring the Therapeutic Potential of Moringa Oleifera in Lead Poisoning: An Investigation of its Effects on Blood Lead Levels and Oxidative Stress in Ratsen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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International Journal of Clinical and Biomedical Research (IJCBR)