ANTI INFLAMMATORY EFFECT OF CIPROFLOXACIN, AZITHROMYCIN AND DICLOFENAC SODIUM ON CARRAGEENAN INDUCED HIND PAW EDEMA IN MICE

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dc.creatorReddy E, Rukma
dc.creatorI, Sridhar
dc.creatorB, Srikanth
dc.date.accessioned2026-01-10T18:52:59Z
dc.date.available2026-01-10T18:52:59Z
dc.date.issued2017-10-25
dc.descriptionBackground: Obviously, antibacterial agents are primarily directed against bacteria. However, because microorganisms can initiate an exaggerated inflammatory reaction, and as pathogens which persist in cryptic reservoirs (cells or granuloma tissue) can be the underlying cause of chronic inflammation, the hypothesis that antibacterials can down regulate inflammation. Methodology: Healthy adult mice weighing 20 - 30 g and aged 6-8 weeks, each group 6 mice were included. 1% carrageenan administered to produce inflammation. Grouping: Group 1: Normal saline 0.2 ml. i.p., Group 2: Diclofenac sodium 25mg/kg, Group 3 Ciprofloxacin 50 mg/kg, Group 4: Azithromycin 20mg/kg. Drugs were administered Intra Peritoneal. After 30 min of test drugs administration each group of mice were received subplantar administration of 0.05ml of saline (Control) or 0.05ml carrageenan (1%) for test groups 2 to 4. Paw volumes were measured by dipping in to the mercury plethysmograph at 30, 60, 120 and 180 minutes and results were tabulated. Results: Diclofenac, ciproflaoxin, Azithromycin inhibited paw edema in % at 30min 42.85, 28.55, 14.28, at 60min 75, 50, 25, at 120min 71.42, 42.85, 14.28, and at 180 min 50, 50, 25 respectively. Conclusion: Ciprofloxacin (50mg/kg) has exhibited consistent anti-inflammatory, but the anti-inflammatory activity of is less than that of Diclofenac sodium and Azithromycin also has exhibited anti-inflammatory activity, though much less when compared to Diclofenac sodium and Ciprofloxacin. Key words: Anti inflammatory effect; Azithromycin; Ciprofloxacin; Diclofenac Sodium; Paw edema; Mice.en-US
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dc.identifierhttps://sumathipublications.com/index.php/ijcbr/article/view/171
dc.identifier10.5455/ijcbr.2017.34.11
dc.identifier.urihttps://repos.sumathipublications.com:8000/handle/123456789/168
dc.languageeng
dc.publisherSumathi Publicationsen-US
dc.relationhttps://sumathipublications.com/index.php/ijcbr/article/view/171/197
dc.relation.ispartofInternational Journal of Clinical and Biomedical Researchen-US
dc.relation.ispartofseriesVolume 3, Issue 4en-US
dc.rightsCopyright (c) 2017 Rukma Reddy E, Sridhar I, Srikanth Ben-US
dc.sourceInternational Journal of Clinical and Biomedical Research; Volume 3, Issue 4; October 2017; 50-53en-US
dc.source2395-0471
dc.source2521-0394
dc.titleANTI INFLAMMATORY EFFECT OF CIPROFLOXACIN, AZITHROMYCIN AND DICLOFENAC SODIUM ON CARRAGEENAN INDUCED HIND PAW EDEMA IN MICEen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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