Alteration of Coagulation Profiles in Hypothyroid Patients

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dc.creatorMohamedahmed, Khalid Abdelsamea
dc.creatorAhmed, Ahmed Hassan
dc.creatorTalha, Albadawi Abdebagi
dc.creatorBabker, Asaad
dc.date.accessioned2026-01-10T19:04:02Z
dc.date.available2026-01-10T19:04:02Z
dc.date.issued2022-06-08
dc.descriptionBackground: Hypothyroidism is an underactive thyroid gland that results in too little thyroid hormones in circulation causing a slowdown in metabolism, therefor hypothyroid modifies physiological process of primary and secondary hemostasis and may lead to a higher bleeding risk. Objectives: The aim of this study is to assess the coagulation profiles [Prothrombin Time (PT), International Normalize Ratio (INR), Activated Partial Thromboplastin Time (PTT)] in patients with hypothyroidism. Methodology: This is a case-control hospital-based study carried out at the National Cancer Institute – University of Gezira (NCI-UG), Wad Medani, Sudan from January to October 2020. A total of 100 (50 patients with hypothyroidism as cases (38.50 ± 10.46 years) matched with 50 normal healthy individuals as controls (35.52 ± 11.64 years) participated in this study. Two ml of venous blood sample was collected in a trisodium citrate container. Coagulation profiles (PT, INR, and PTT) were measured using a Coatron M4 coagulometer. SPSS computer program (v 21.0) was used for data analysis. Results: The prolonged PTT account for 74%. The average PTT of cases (42.29 ± 7.22 sec) was higher than controls (32.67 ± 5.90 sec) giving highly statistically significant differences (P value = 0.000) between them. There were significant differences in PTT between mild and severe hypothyroidism (P value = 0.0470). PTT had significant positive correlation within TSH (P value = 0.048; r = 0.070) and significant negative correlation within T3 (P value = 0.000; r = - 0.490) and T4 (P value = 0.020; r = - 520; P value = 000). Conclusion: The study concluded that PTT was significantly higher in a patient with hypothyroidism when compared to the control. PTT results showed there was a significant negative correlation between T3 and T4 levels and a significant positive correlation with TSH levels. So, PTT should be included as a follow-up routine test for patients with hypothyroidism. Keywords: Prothrombin time, International Normalized Ratio, Partial Thromboplastin Time, Hypothyroidism, Sudan.en-US
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dc.identifierhttps://sumathipublications.com/index.php/ijcrpp/article/view/433
dc.identifier.urihttps://repos.sumathipublications.com:8000/handle/123456789/244
dc.languageeng
dc.publisherSumathi Publicationsen-US
dc.relationhttps://sumathipublications.com/index.php/ijcrpp/article/view/433/420
dc.relationhttps://sumathipublications.com/index.php/ijcrpp/article/view/433/446
dc.relation.ispartofInternational Journal of Current Research in Physiology and Pharmacologyen-US
dc.relation.ispartofseriesVolume 6, Issue 2en-US
dc.rightsCopyright (c) 2022 Asaad Babkeren-US
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceInternational Journal of Current Research in Physiology and Pharmacology; Volume 6, Issue 2; 2022; 1-5en-US
dc.source2523-6709
dc.source2523-6695
dc.subjectProthrombin timeen-US
dc.subjectINRen-US
dc.subjectHypothyroidismen-US
dc.subjectSudanen-US
dc.subjectPTTen-US
dc.subjectInternational normalised ratioen-US
dc.titleAlteration of Coagulation Profiles in Hypothyroid Patientsen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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