Atrazine derangement of GLUT-4 and Insulin metabolism and the ameliorative effect of Virgin coconut oil in male wistar rats

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dc.creatorOlatunbosun, Titilope
dc.creatorOsim, Eme Effiom
dc.creatorAsuquo, Asuquo Etim
dc.creatorUtibe, David Jessica
dc.date.accessioned2026-01-10T19:04:01Z
dc.date.available2026-01-10T19:04:01Z
dc.date.issued2021-09-30
dc.descriptionWe assessed the ameliorative effect of Virgin Coconut Oil following atrazine-induced metabolic derangement in rats. Adult male wistar rats weighing 180-200g were used; randomly separated into two major groups. Thirty-five rats in the test group were randomly divided into five sub-groups of 7 rats per sub-group and treated thus: Sub-group (SG) 1, 2 and 3 received 10ml/kg of distilled water, 10ml/kg VCO, 123mg/kg of Atrazine respectively, SG4 was diabetic control; SG 5 was the diabetic group treated with 10ml/kg of VCO for 2 weeks, after which the animals were sacrificed and blood collected for analysis. 35 rats for the recovery group were also divided into 5 sub-groups of 7 rats per sub-group and were treated; SG 1, 2, 3, 4 and 5 received 10ml/kg distilled water, 10ml/kg VCO, 123mg/kg of ATZ respectively. After 2 weeks, the animals were re-treated thus: SG 1,2,3,4 and 5 received 10ml/kg of distilled water, 10ml/kg of VCO, 123mg/kg of ATZ, 10ml/kg VCO and 10ml/kg distilled water respectively. After 2 weeks, the animals were also sacrificed and blood collected for analysis. ATZ reduced serum insulin and a reduced expression of GLUT4. VCO restored GLUT4 levels but did not significantly restore the insulin to the normal levelsen-US
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dc.identifierhttps://sumathipublications.com/index.php/ijcrpp/article/view/415
dc.identifier10.31878/ijcrpp.2021.53.01
dc.identifier.urihttps://repos.sumathipublications.com:8000/handle/123456789/242
dc.languageeng
dc.publisherSumathi Publicationsen-US
dc.relationhttps://sumathipublications.com/index.php/ijcrpp/article/view/415/409
dc.relationhttps://sumathipublications.com/index.php/ijcrpp/article/view/415/481
dc.relationhttps://sumathipublications.com/index.php/ijcrpp/article/view/415/482
dc.relation.ispartofInternational Journal of Current Research in Physiology and Pharmacologyen-US
dc.relation.ispartofseriesVolume 5, Issue 3en-US
dc.rightsCopyright (c) 2021 Titilope Olatunbosun, Prof Eme Osim, Asuquo Etim Asuquo, David Jessica Utibeen-US
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceInternational Journal of Current Research in Physiology and Pharmacology; Volume 5, Issue 3; 2021; 1-9en-US
dc.source2523-6709
dc.source2523-6695
dc.subjectGLUT-4en-US
dc.subjectInsulinen-US
dc.subjectAtrazineen-US
dc.subjectVirgin Coconut Oilen-US
dc.subjectDiabetesen-US
dc.subjectGlucoseen-US
dc.titleAtrazine derangement of GLUT-4 and Insulin metabolism and the ameliorative effect of Virgin coconut oil in male wistar ratsen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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