Epilepsy and Neuroinflammation: Unraveling the Complex Connection

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dc.creatorMashooq Ahmad Mir
dc.creatorBashir Malik, Abrar
dc.creatorQadrie, Zulfkar
dc.creatorAltaf Dar, Mohd
dc.date.accessioned2026-01-10T19:04:09Z
dc.date.available2026-01-10T19:04:09Z
dc.date.issued2023-09-30
dc.descriptionABSTRACT Epilepsy, a neurological disorder characterized by recurring seizures, has long been a subject of scientific exploration. Recent research has unveiled an intriguing link between epilepsy and neuroinflammation, the brain's immune response to injury or infection. This connection has shed light on how inflammation contributes to the development and progression of epilepsy. Neuroinflammation appears to play a pivotal role in epileptogenesis—the process of normal brain tissue becoming hyperexcitable and prone to seizures. Immune cells like microglia and astrocytes release inflammatory molecules that disrupt neurotransmitter balance, promoting neuronal hyperexcitability. This heightened excitability sets the stage for seizure generation. The interaction between neuroinflammation and seizures is bidirectional. Seizures can trigger immune responses, releasing pro-inflammatory molecules. Conversely, inflammation lowers the seizure threshold, making individuals more susceptible to seizures. Mechanisms underlying this relationship include blood-brain barrier dysfunction, altered synaptic plasticity, and an imbalance between excitatory and inhibitory signaling. Understanding these mechanisms has therapeutic implications. Targeting neuroinflammatory pathways could suppress inflammation and reduce seizure frequency. Neuroprotective agents may prevent inflammation-induced damage and halt epileptogenesis. Immunomodulatory treatments might restore the balance between pro- and anti-inflammatory responses, regulating neuroinflammation and reducing seizure susceptibility. The intricate interplay between epilepsy and neuroinflammation is a captivating field of study. Unraveling this complex connection offers insights into the underlying mechanisms of epilepsy, potentially leading to novel therapeutic approaches. By addressing both neurological and inflammatory aspects, researchers aim to improve epilepsy management and enhance the lives of those affected by this condition. Keywords: Epilepsy, neuroinflammation, seizures, inflammation.en-US
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dc.identifierhttps://sumathipublications.com/index.php/ijcrpp/article/view/476
dc.identifier.urihttps://repos.sumathipublications.com:8000/handle/123456789/268
dc.languageeng
dc.publisherSumathi Publicationsen-US
dc.relationhttps://sumathipublications.com/index.php/ijcrpp/article/view/476/608
dc.relationhttps://sumathipublications.com/index.php/ijcrpp/article/view/476/613
dc.relation.ispartofInternational Journal of Current Research in Physiology and Pharmacologyen-US
dc.relation.ispartofseriesVolume 7, Supplement 2en-US
dc.rightsCopyright (c) 2023 Mashooq Ahmad Mir, Abrar Bashir Malik, Zulfkar Qadrie, Mohd Altaf Daren-US
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceInternational Journal of Current Research in Physiology and Pharmacology; Volume 7, Supplement 2; 2023; 3-9en-US
dc.source2523-6709
dc.source2523-6695
dc.subjectEpilepsy, neuroinflammation, seizures, inflammation.en-US
dc.titleEpilepsy and Neuroinflammation: Unraveling the Complex Connectionen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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