Anti-inflammatory activity of Ocimum sanctum (Linn) in formalin induced acute models of albino rats

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dc.creatorM MIRJE, MRUTYUNJAY
dc.creatorKUMBAR, SHIVAPRASAD
dc.creatorMOHARIR, GURUDATTA
dc.date.accessioned2026-01-10T18:52:13Z
dc.date.available2026-01-10T18:52:13Z
dc.date.issued2015-01-11
dc.descriptionThe inflammatory process is the response to an injurious stimulus. It can be evoked by a wide variety of noxious agents (e.g., infections, antibodies, physical injuries). Many nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, phenylbutazone, indomethacin etc. are in clinical use but all these are not completely devoid of adverse effects. In this study, the anti-inflammatory activity of O. sanctum alone and in combination with indomethacin was studied using formalin-induced rat paw edema. Aqueous extract of O. sanctum (200mg/kg, 300mg/kg  or 400mg/kg) was administered alone and in combination with indomethacin (25mg/kg) to separate group of rats and paw volume was measured by plethysmometer and compared with control group. All the test groups showed significant (P<0.05) anti-inflammatory effect in formalin-induced rat paw edema. The reduction of edema by O. sanctum was better than that of the standard anti-inflammatory drug, indomethacin and on co-administration marginally improved the anti-inflammatory profile of indomethacin. O.sanctum possesses significant anti-inflammatory activity probably due to inhibition of both cyclooxygenase and lipooxygenase pathways of arachidonic acid metabolism (dual inhibitory property). KEYWORDS: Nonsteroidal anti-inflammatory drugs (NSAIDs); Indomethacin; Plethysmometer.en-US
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dc.identifierhttps://sumathipublications.com/index.php/ijcbr/article/view/41
dc.identifier.urihttps://repos.sumathipublications.com:8000/handle/123456789/38
dc.languageeng
dc.publisherSumathi Publicationsen-US
dc.relationhttps://sumathipublications.com/index.php/ijcbr/article/view/41/60
dc.relationhttps://sumathipublications.com/index.php/ijcbr/article/view/41/456
dc.relationhttps://sumathipublications.com/index.php/ijcbr/article/view/41/458
dc.relation.ispartofInternational Journal of Clinical and Biomedical Researchen-US
dc.relation.ispartofseriesVolume 1, Issue 1en-US
dc.rightsCopyright (c) 2015 MRUTYUNJAY M MIRJE, SHIVAPRASAD KUMBAR, GURUDATTA MOHARIRen-US
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceInternational Journal of Clinical and Biomedical Research; Volume 1, Issue 1; January 2015; 1-4en-US
dc.source2395-0471
dc.source2521-0394
dc.subjectNonsteroidal anti-inflammatory drugs (NSAIDs); Indomethacin; Plethysmometer.en-US
dc.titleAnti-inflammatory activity of Ocimum sanctum (Linn) in formalin induced acute models of albino ratsen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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International Journal of Clinical and Biomedical Research (IJCBR)