LIPID PEROXIDE LEVELS AND ANTIOXIDANT STATUS IN HEALTHY AND ALCOHOLIC HEPATITIS PATIENTS

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dc.creatorbhatt, Sanjay
dc.creatorM Itagappa, Itagappa
dc.creatorGogoi, J. B.
dc.creatorSati, Bindu
dc.date.accessioned2026-01-10T18:52:56Z
dc.date.available2026-01-10T18:52:56Z
dc.date.issued2017-10-25
dc.descriptionBackground: Alcohol remains the single most significant cause of liver disease throughout the Western world, responsible for between 40 and 80% of cases of cirrhosis in different countries. Material & Methods:The study was conducted in Department of Biochemistry, Santosh medical college & Hospital, Ghaziabad and Veer Chandra Singh Garhwali Govt. Institute of Medical Sciences & Research, 164 alcoholic hepatitis patients were subjected to detailed clinical examination and laboratory investigations and the results were compared with 82controls. Blood samples were collected for oxidative stress parameters. It was observed that there was a significant increase in activities of Catalase, SOD, MDA, GPX and GR activity in patients with alcoholic hepatitis when compared to controls. Results: Results of our study show higher oxygen free radical production, evidenced by elevated levels of MDA and decreased levels of Catalase, SOD, GPx, GR, and TAS activity, supporting the evidence of oxidative stress in alcoholic hepatitis patients. Decreased concentrations of antioxidant support the hypothesis that alcoholic hepatitis is an important causative factor in pathogenesis of lipid peroxidation. Conclusion: Theantioxidant defense mechanisms might be impaired in patients with alcoholic hepatitis. These findings also provide a theoretical basis for development of novel therapeutic strategies, such as antioxidant supplementation. Keywords: Alcoholic Hepatitis; Catalase; Glutathione Peroxidase; Glutathione Reductase; Malondialdehyde; Superoxide dismutase; Total antioxidant status.en-US
dc.formatapplication/pdf
dc.identifierhttps://sumathipublications.com/index.php/ijcbr/article/view/163
dc.identifier10.5455/ijcbr.2017.34.03
dc.identifier.urihttps://repos.sumathipublications.com:8000/handle/123456789/160
dc.languageeng
dc.publisherSumathi Publicationsen-US
dc.relationhttps://sumathipublications.com/index.php/ijcbr/article/view/163/189
dc.relation.ispartofInternational Journal of Clinical and Biomedical Researchen-US
dc.relation.ispartofseriesVolume 3, Issue 4en-US
dc.rightsCopyright (c) 2017 Sanjay bhatt, Itagappa M Itagappa, J. B. Gogoi, Bindu Satien-US
dc.sourceInternational Journal of Clinical and Biomedical Research; Volume 3, Issue 4; October 2017; 10-13en-US
dc.source2395-0471
dc.source2521-0394
dc.titleLIPID PEROXIDE LEVELS AND ANTIOXIDANT STATUS IN HEALTHY AND ALCOHOLIC HEPATITIS PATIENTSen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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