Effect of sildenafil citrate on prediabetic and diabetic albino rats treated with metformin

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dc.creatortaha, ahmed mohmed
dc.creatorHaredy, Haredy Hassan
dc.creatorGhareip, Ahmed
dc.creatorel-deen, Ahmed El sayed Nour
dc.creatorAshour, Yasser M
dc.date.accessioned2026-01-10T19:04:00Z
dc.date.available2026-01-10T19:04:00Z
dc.date.issued2021-03-07
dc.descriptionDiabetes Miletus (DM) is a global epidemic disease. It is estimated that there are already 415 million adults aged 20–79 years diabetics worldwide. Sildenafil citrate is a phosphodiesterase type 5 (PDE5) inhibitor, which increases cyclic guanosine monophosphate (cGMP) and metformin (MET) is a biguanide used for the treatment of type 2 diabetes which increases peripheral insulin sensitivity. Aim: This study aims to assess the effect of sildenafil citrate and metformin on lipid profile and glycemic control in diabetic and prediabetic albino rats. Materials and methods: Adult male albino rats are used and divided into nine groups each group consists of 10 rats, diabetes is induced by feeding a high-fat diet (HFD) for an initial period of 2 weeks followed by a single intraperitoneal injection of (35 mg/kg) Streptozotocin. Prediabetes is induced by feeding (HFD) and glucose in water for a period of 2 weeks. Sildenafil was given in a dose of (5 &10 mg/kg/day orally for 4 weeks), metformin was given in a dose of (50 &100 mg/kg/day orally for 4 weeks) using oral gavages to normal healthy rats, diabetic and prediabetic rats. Blood samples were collected after 4 weeks of treatment in all experimental groups. Results: Combined administration of sildenafil and metformin on diabetic rats improving hyperglycemia, oxidative stress, and hyperlipidemia induced by streptozotocin than the administration of metformin or sildenafil alone. Conclusion: Sildenafil has beneficial effects against some diabetic complications. The present study showed that sildenafil with metformin has beneficial effects against diabetic complications.en-US
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dc.identifierhttps://sumathipublications.com/index.php/ijcrpp/article/view/398
dc.identifier10.31878/ijcrpp.2021.51.02
dc.identifier.urihttps://repos.sumathipublications.com:8000/handle/123456789/239
dc.languageeng
dc.publisherSumathi Publicationsen-US
dc.relationhttps://sumathipublications.com/index.php/ijcrpp/article/view/398/395
dc.relation.ispartofInternational Journal of Current Research in Physiology and Pharmacologyen-US
dc.relation.ispartofseriesVolume 5, Issue 1en-US
dc.rightsCopyright (c) 2021 Ahmed Mohmed Taha, Haredy Hassan Haredy, Ahmed Ghareip, Ahmed El sayed Nour el-deen, Yasser M Ashouren-US
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceInternational Journal of Current Research in Physiology and Pharmacology; Volume 5, Issue 1; 2021.en-US
dc.source2523-6709
dc.source2523-6695
dc.subjectDiabetes Mellitusen-US
dc.subjectDMen-US
dc.subjectSildenafilen-US
dc.subjectMetforminen-US
dc.titleEffect of sildenafil citrate on prediabetic and diabetic albino rats treated with metforminen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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