ACID SENSING ION CHANNELS (ASICS): POTENTIAL TARGETS FOR THE DISCOVERY OF NOVEL THERAPEUTICS IN DISEASE MANAGEMENT

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dc.creatorRoy, Debendra Nath
dc.date.accessioned2026-01-10T18:52:39Z
dc.date.available2026-01-10T18:52:39Z
dc.date.issued2018-01-24
dc.descriptionAcid sensing ion channels (ASIC) are Na+ channels activated by external protons. Number of neurological (pathological pain, expression of fear, anxiety, depression, and neurodegeneration after ischemic stroke etc) and non -neurological (brain tumor, cardiovascular mechanosensation, hypoxia induced hypertension, glaucoma, etc.) disorders are implicated by various ASICs subtypes. Due to heir known and potential roles in many disease pathologies, it is very authentic to explore the importance of new and selective small molecule inhibitors and even activators of ASICs as a research tool in clinical uses for treating these diseases pathogenesis. This review is aimed to find out the therapeutic potentialities of ASICs argeed novel drugs in contex of their pathophysiological role in human body. Fluorescent dyes and optical sensors as a means of fast and efficient screening approaches would certainly be used to improve he discovery technology of ASICs modulated drugs.en-US
dc.formatapplication/pdf
dc.identifierhttps://sumathipublications.com/index.php/ijcbr/article/view/110
dc.identifier10.5455/ijcbr.2018.41.13
dc.identifier.urihttps://repos.sumathipublications.com:8000/handle/123456789/107
dc.languageeng
dc.publisherSumathi Publicationsen-US
dc.relationhttps://sumathipublications.com/index.php/ijcbr/article/view/110/137
dc.relation.ispartofInternational Journal of Clinical and Biomedical Researchen-US
dc.relation.ispartofseriesVolume 4, Issue 1en-US
dc.rightsCopyright (c) 2018 Debendra Nath Royen-US
dc.sourceInternational Journal of Clinical and Biomedical Research; Volume 4, Issue 1; January 2018; 62-68en-US
dc.source2395-0471
dc.source2521-0394
dc.titleACID SENSING ION CHANNELS (ASICS): POTENTIAL TARGETS FOR THE DISCOVERY OF NOVEL THERAPEUTICS IN DISEASE MANAGEMENTen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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