Total body irradiation in a case of thalassemia major with source to axis distance based planning: A case report

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dc.creatorVirkar, Mayuresh D.
dc.creatorChauhan, Rajkumar
dc.creatorChadha, Pranav
dc.creatorTalapatra, Kaustav
dc.creatorRodrigues, Reuben Jake
dc.creatorShrivastava, Amrita
dc.creatorSen, Santanu
dc.creatorTulpule, Sameer
dc.date.accessioned2026-01-10T19:35:48Z
dc.date.available2026-01-10T19:35:48Z
dc.date.issued2020-10-29
dc.descriptionBackground: The use of total body radiation (TBI) before hematopoietic stem cell transplantation (HSCT) would increase the engraftment without transplant-related morbidity or mortality among Thalassemia major (TM) cases. Case presentation: A 2-year-old female child, diagnosed with TM was scheduled for haploidentical allogenic transplant-based protocol, and after that, based on protocol she was scheduled to undergo a single session of TBI as a conditioning regimen before haploidentical allogenic hematopoietic stem cell tranplant. A total dose of 4 Gy was administered.. The incidence of graft failure was reduced as TBI was used before allogeneic stem cell transplantation. TBI provided a uniform dose of radiation to the entire body, penetrating areas such as the central nervous system (CNS) and testes. Conclusion: Total Body Irradiation with the SAD technique is the most effective way of treatment. As it is comfortable for the patient to undergo, easily reproducible, and it helps to achieve a uniform dose distribution.en-US
dc.formatapplication/pdf
dc.identifierhttps://sumathipublications.com/index.php/ijcbr/article/view/393
dc.identifier10.31878/ijcbr.2020.64.06
dc.identifier.urihttps://repos.sumathipublications.com:8000/handle/123456789/355
dc.languageeng
dc.publisherSumathi Publicationsen-US
dc.relationhttps://sumathipublications.com/index.php/ijcbr/article/view/393/386
dc.relation.ispartofInternational Journal of Clinical and Biomedical Researchen-US
dc.relation.ispartofseriesVolume 6, Issue 4en-US
dc.rightsCopyright (c) 2020 Mayuresh D. Virkar, Rajkumar Chauhan, Pranav Chadha, Kaustav Talapatra, Reuben Jake Rodrigues, Amrita Shrivastava, Santanu Sen, Sameer Tulpuleen-US
dc.sourceInternational Journal of Clinical and Biomedical Research; Volume 6, Issue 4; October 2020.; 25-28en-US
dc.source2395-0471
dc.source2521-0394
dc.subjectHematopoietic Stem Cell Transplantation; Graft-versus-Host Disease; Thalassemia Minor;en-US
dc.subjectRadiotherapy; Myeloablative conditioning; Haemoglobinopathiesen-US
dc.titleTotal body irradiation in a case of thalassemia major with source to axis distance based planning: A case reporten-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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