ANTIEPILEPTIC EFFECT OF CALCIUM CHANNEL BLOCKERS ALONE AND IN COMBINATION WITH PHENYTOIN ON MES INDUCED EPILEPSY IN RATS

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dc.creatorUppin, Vijayalaxmi
dc.creatorAA, Naikawadi
dc.creatorBharatha, Ambadasu
dc.date.accessioned2026-01-10T18:52:50Z
dc.date.available2026-01-10T18:52:50Z
dc.date.issued2017-07-28
dc.descriptionBackground: The currently available antiepileptic drugs have a low therapeutic index, and provide satisfactory seizure control in only 60-70% of patients. Calcium channel blocker has shown potentials of a useful add-on drug for the existing antiepileptic drugs. Objectives: To study the effect of calcium channel blockers (CCBs) nifedipine and verapamil on maximal electroshock (MES)-induced convulsions and also to evaluate their effect in combination with Phenytoin. Methods: For this study, Male Wistar rats were used. Effects of nifedipine (5 mg/kg), verapamil (20mg/kg) alone and in combination with phenytoin (25mg/kg) were studied in MES model. Abolition of hind limb tonic extension and reduction of duration of tonic extension was considered as the index for antiepileptic activity in MES. Results: Verapamil and nifedipine produced significant antiepileptic effect alone. Verapamil and nifedipine potentiated the antiepileptic effect of phenytoin sodium. Conclusion: Dose of phenytoin sodium can be reduced in epileptic patients receiving verapamil or nifedipine for some other clinical conditions. Verapamil and nifedipine can also be used alone in the treatment of generalized tonic clonic seizures. However it needs further confirmation to establish clinical utility of calcium channel blockers. KEY WORDS: Nifedipine, verapamil, phenytoin, MES seizure rats.en-US
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dc.identifierhttps://sumathipublications.com/index.php/ijcbr/article/view/151
dc.identifier10.5455/ijcbr.2017.33.04
dc.identifier.urihttps://repos.sumathipublications.com:8000/handle/123456789/148
dc.languageeng
dc.publisherSumathi Publicationsen-US
dc.relationhttps://sumathipublications.com/index.php/ijcbr/article/view/151/177
dc.relation.ispartofInternational Journal of Clinical and Biomedical Researchen-US
dc.relation.ispartofseriesVolume 3, Issue 3en-US
dc.rightsCopyright (c) 2017 Vijayalaxmi Uppin, Naikawadi AA, Ambadasu Bharathaen-US
dc.sourceInternational Journal of Clinical and Biomedical Research; Volume 3, Issue 3; July 2017; 9-12en-US
dc.source2395-0471
dc.source2521-0394
dc.titleANTIEPILEPTIC EFFECT OF CALCIUM CHANNEL BLOCKERS ALONE AND IN COMBINATION WITH PHENYTOIN ON MES INDUCED EPILEPSY IN RATSen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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International Journal of Clinical and Biomedical Research (IJCBR)