PREVENTIVE EFFECTS OF THE AQUEOUS EXTRACT OF CINNAMOMUM ZEYLANICUM BARK ON DEXAMETHASONE INDUCED INSULIN RESISTANCE IN WISTAR ALBINO RATS

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dc.creatorCH, Rajasekhar
dc.creatorIM, Nagendranayak
dc.creatorB, Rajesh
dc.creatorB Nagraju, Kokila
dc.creatorN Banavasi, Guruprasad
dc.creatorKumar V, Hemanth
dc.date.accessioned2026-01-10T18:52:29Z
dc.date.available2026-01-10T18:52:29Z
dc.date.issued2015-10-28
dc.descriptionObjectives: To evaluate the preventive effects of aqueous extract of Cinnamomum zeylanicum bark on dexamethasone induced insulin resistance and to compare it with rosiglitazone. Methods: The animals were categorized into two series of dexamethasone (dexamethasone 4mg/kg, dexamethasone 8mg/kg series) with 5 groups in each [plain control, dexamethasone 4/8mg/kg as per series, rosiglitazone 8mg/kg and 16mg/kg, cinnamon bark extract (CZE) 250mg/kg BW]. Six animals were studied in each group. In a12 day study period, rosiglitazone and CZE groups received respective drug treatments and dexamethasone dosing (4mg/kg or 8mg/kg) was started from day 7onwards. On day 12, fasting blood, urine and post IPGTT blood samples were collected and processed for glucose, insulin and ketone estimations. Results: In both series, CZE 250mg/kg treatment showed significant reduction in mean fasting glucose and insulin compared to rosiglitazone 8mg/kg and 16mg/kg groups and dexamethasone controls (4mg/kg, 8mg/kg groups) (P<0.05). The fall in glucose and insulin levels observed with CZE treatment at 30, 60 min post IPGTT in both series were significant compared to rosiglitazone and dexamethasone treatment groups (P<0.05). Glycosuria and ketonuria were absent in CZE groups, whereas these were reduced significantly in rosiglitazone groups compared to dexamethasone groups (P<0.05). Conclusion: The aqueous extract of C. zeylanicum bark prevented the insulin resistance as evidenced by reduced fasting and post IPGTT glucose and insulin levels in steroid induced insulin resistance model. KEYWORDS: Glucose uptake; Cinnamon bark; Rosiglitazone; Hyperinsulinemia; Hyperglycemia.en-US
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dc.identifierhttps://sumathipublications.com/index.php/ijcbr/article/view/87
dc.identifier.urihttps://repos.sumathipublications.com:8000/handle/123456789/84
dc.languageeng
dc.publisherSumathi Publicationsen-US
dc.relationhttps://sumathipublications.com/index.php/ijcbr/article/view/87/114
dc.relation.ispartofInternational Journal of Clinical and Biomedical Researchen-US
dc.relation.ispartofseriesVolume 1, Issue 4en-US
dc.rightsCopyright (c) 2015 Rajasekhar CH, Nagendranayak IM, Rajesh B, Kokila B Nagraju, Guruprasad N Banavasi, Hemanth Kumar Ven-US
dc.sourceInternational Journal of Clinical and Biomedical Research; Volume 1, Issue 4; October 2015; 14-20en-US
dc.source2395-0471
dc.source2521-0394
dc.titlePREVENTIVE EFFECTS OF THE AQUEOUS EXTRACT OF CINNAMOMUM ZEYLANICUM BARK ON DEXAMETHASONE INDUCED INSULIN RESISTANCE IN WISTAR ALBINO RATSen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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