2026-01-102026-01-102020-02-23https://repos.sumathipublications.com:8000/handle/123456789/227ABSTRACT: Introduction: Heat stress is a major health burden with potential health out-comes. Oxidative stress is a metabolic dysfunction that carries oxidative damage of cells and tissues. Zinc is a co-factor against oxidative stress. Aim: The present study was done to evaluate the Supplementation of zinc in acute and chronic heat stress on antioxidant changes in wistar albino rats. Methodology: 36 Wistar albino rats were selected for the study. They were divided into 2 Groups. Group A was acutely and Group B was chronically heat stressed rats and both were zinc pretreated. The Enzymatic and Non enzyme activity in them were estimated. Results: After acute and chronic heat stress, i) there was a significant increase (P <0.001) in lipid peroxidation activity. ii) Enzymatic and Non-enzymatic antioxidants were reduced (P < 0.001) iii) Rats pretreated with zinc showed a decrease (P< 0.001) in lipid peroxidation and increase (P < 0.001) in enzymatic antioxidants (P < 0.001) and Non enzymatic antioxidants. Key Words: antioxidants, heat stress, wistar albino ratsapplication/pdfCopyright (c) 2020 antony madhuri bedadala; Dr Anthony David, DOCTORhttp://creativecommons.org/licenses/by-nc-sa/4.0antioxidantsheat stresswistar albino ratsinfo:eu-repo/semantics/article